Sibofix 400 Tablet

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    Sibofix 400 Tablet Information

    Sibofix 400 Tablet is a commercial drug that is prescribed in the form of Tablet. It is primarily used for the treatment of Hepatic Encephalopathy. Secondary and off-label uses of Sibofix 400 Tablet have also been mentioned below.

    The right dosage of Sibofix 400 Tablet depends on the age, gender, and medical history of the patient. Dosage also depends on the route of administration and your chief complaint for which the drug is prescribed. This information has been provided in detail in the dosage section.

    The side effects typically associated with Sibofix 400 Tablet include Flatulence, Bloating or fullness, Constipation. Some other side effects of Sibofix 400 Tablet have been listed ahead. Usually, these side effects of Sibofix 400 Tablet go away soon, and do not persist beyond the duration of the treatment. If, however, they worsen or do not go away, please speak with your physician.

    Furthermore, you should know that effect of Sibofix 400 Tablet is Severe for pregnant women and Severe for women who are breastfeeding. Further, the section on Sibofix 400 Tablet related warnings talks about Sibofix 400 Tablet's effects on the liver, heart and kidney.

    Other conditions have been mentioned below in the Sibofix 400 Tablet contraindications section.

    Additionally, Sibofix 400 Tablet may also adversely react with other medicines. See below for a complete list.

    In addition to these precautions, you may also note that Sibofix 400 Tablet is safe while driving, and is is addictive in nature.



    Sibofix 400 Tablet Benefits & Uses

    Sibofix 400 Tablet is used to treat the following -

    Main Benefits

    Other Benefits

    Sibofix 400 Tablet Dosage & How to Take

    This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

    Find the right dosage based on disease and age

    Age Group Dosage
    Adult
    • Disease: Traveler's Diarrhea
    • Before or After Meal: Either
    • Single Maximum Dose: 200 g
    • Dosage Form: Tablet
    • Dosage Route: Oral
    • Frequency: 3 daily
    • Course Duration: 3 days
    • Special Instructions: As prescribed by the doctor
    13 - 18 years (Adolescent)
    • Disease: Traveler's Diarrhea
    • Before or After Meal: Either
    • Single Maximum Dose: 200 mg
    • Dosage Form: Tablet
    • Dosage Route: Oral
    • Frequency: 2 daily
    • Course Duration: 3 days
    • Special Instructions: As prescribed by the doctor
    Geriatric
    • Disease: Traveler's Diarrhea
    • Before or After Meal: Either
    • Single Maximum Dose: 200 mg
    • Dosage Form: Tablet
    • Dosage Route: Oral
    • Frequency: 3 daily
    • Course Duration: 3 days
    • Special Instructions: As prescribed by the doctor

    Sibofix 400 Tablet Related Warnings

    • Is the use of Sibofix 400 Tablet safe for pregnant women?


      Sibofix shows severe side effect on pregnant women. For this reason, pregnant women should only take it after taking medical advice.

      Severe
    • Is the use of Sibofix 400 Tablet safe during breastfeeding?


      Sibofix may cause serious side effects in breastfeeding women, so do not take this drug without doctor's advice.

      Severe
    • What is the effect of Sibofix 400 Tablet on the Kidneys?


      Sibofix does not damage the kidneys.

      Safe
    • What is the effect of Sibofix 400 Tablet on the Liver?


      Very few cases of side effects of Sibofix on the liver have been reported.

      Mild
    • What is the effect of Sibofix 400 Tablet on the Heart?


      You can take Sibofix without any fear of damage to the heart.

      Safe


    Sibofix 400 Tablet Contraindications

    If you are suffering from any of the following diseases, you should not take Sibofix 400 Tablet unless your doctor advises you to do so -



    Frequently asked Questions about Sibofix 400 Tablet

    • Is this Sibofix 400 Tablet habit forming or addictive?


      Sibofix 400 Tablet does not cause addiction.

      No
    • Is it safe to drive or operate heavy machinery when consuming?


      Sibofix 400 Tablet will not make you feel sleepy or drowsy. So you drive or operate machinery safely.

      Safe
    • Is it safe?


      Yes, but take Sibofix 400 Tablet only as per medical advice.

      Safe, but take only on Doctor's advise
    • Is it able to treat mental disorders?


      No, Sibofix 400 Tablet cannot treat any kind of mental disorder.

      No

    Sibofix 400 Tablet Interactions with Food and Alcohol

    • Interaction between Food and Sibofix 400 Tablet


      Taking Sibofix 400 Tablet with food does not cause any problems.

      Safe
    • Interaction between Alcohol and Sibofix 400 Tablet


      Information about the interaction of Sibofix 400 Tablet and alcohol is not currently available because this topic has not been researched yet.

      Unknown


    Frequently asked Questions about Sibofix 400 Tablet

    Question over 4 years ago

    Can I take Sibofix with amoxicillin?

    Dr. Vipin Khadse MBBS , General Physician

    Yes, Sibofix can be taken with amoxicillin. No clinically significant drug interaction has been reported between them. However, if you feel any discomfort after taking this drug along with amoxicillin then do not hesitate to inform your doctor.

    Question almost 5 years ago

    Does Sibofix cause weight gain?

    Dr. Haleema Yezdani MBBS , General Physician

    No, Sibofix does not cause weight gain. It has not been reported by the patients who are taking this drug but Sibofix has been reported to cause weight loss in a few patients with travelers’ diarrhea. If you notice any unusual rapid weight changes after taking this drug then discuss with it your doctor and follow his/her instructions.

    Question over 5 years ago

    What is Sibofix?

    Dr. Anand Singh MBBS , General Physician

    Sibofix is a brand name of rifaximin and it comes in the form of tablet and syrup. It is a prescription drug and a broad-spectrum antibiotic which is used in the prevention of travelers’ diarrhea (TD) caused by bacteria Escherichia coli and to reduce the risk of hepatic encephalopathy (a brain disorder that causes decline in functioning of the brain due to accumulation of ammonia in which results from the liver damage) along with lactulose. It is also used in the treatment of irritable bowel syndrome with diarrhea (IBS-D). 

    Question over 4 years ago

    Is Sibofix a penicillin?

    Dr. Chinmaya Bal MBBS , General Physician

    No, Sibofix is not a penicillin. It contains rifaximin which is a broad spectrum antibiotic and an analog of rifampicin. It is a prescription drug that is used in the treatment of travelers’ diarrhea (TD), hepatic encephalopathy, and irritable bowel syndrome with diarrhea (IBS-D).

    Question about 4 years ago

    Can I take Sibofix with loperamide?

    Dr. MBBS , General Physician, Other, Obstetrics & Gynaecology

    Yes, Sibofix can be taken with loperamide. Loperamide does not appear to interfere with the efficacy of Sibofix. Hence, it is alright to take them together. However, if you feel any discomfort after taking this drug do not hesitate to inform your doctor.



    See all substitutes for Sibofix



    This medicine data has been created by -

    Vikas Chauhan

    B.Pharma, Pharmacy
    5 Years of Experience



    References

    US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Xifaxan® (rifaximin)

    KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 681-683

    April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 1096-1097

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