Parbraze 150mg Tablet

Parbraze, containing the active ingredient Olaparib, is a PARP (poly ADP-ribose polymerase) inhibitor used primarily in cancer treatment. It is indicated for the treatment of certain types of ovarian, breast, prostate, and pancreatic cancers. Olaparib works by preventing cancer cells from repairing their DNA, leading to cell death.

Uses

• Ovarian Cancer: For patients with BRCA-mutated advanced ovarian cancer.

• Breast Cancer: Treatment of HER2-negative metastatic breast cancer with germline BRCA mutations.

• Prostate Cancer: For metastatic castration-resistant prostate cancer (mCRPC) with BRCA1/2 mutations.

• Pancreatic Cancer: Used in patients with germline BRCA-mutated metastatic pancreatic cancer.

Mechanism of Action

Olaparib inhibits the PARP enzyme involved in DNA repair. In cells deficient in homologous recombination repair (such as those with BRCA mutations), this leads to DNA damage accumulation and apoptosis.

Dosage

General Dosage:

• Tablets (100 mg, 150 mg): 300 mg taken orally twice daily.

Dosage adjustments may be required in cases of renal or hepatic impairment.

Side Effects

• Common Side Effects: Fatigue, nausea, anemia, vomiting, diarrhea, and decreased appetite.

• Serious Side Effects: Myelodysplastic syndrome, acute myeloid leukemia, and pneumonitis.

Precautions

• Pregnancy: Not recommended due to potential fetal harm.

• Breastfeeding: Avoid breastfeeding during treatment and for some time after.

• Blood Disorders: Monitor for signs of anemia or other hematological abnormalities.

Onset and Duration of Action

• Onset of Action: Therapeutic effects depend on cancer type and stage.

• Duration of Action: Continuous as long as therapy is maintained.

Contraindications

• Known hypersensitivity to Olaparib or its excipients.

• Pregnancy and lactation.

Storage

• Store below 30°C (86°F) in a dry place.

• Protect from moisture and light.