Benzace 40mg Tablet

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Benzace 40mg Tablet Information

Benzace contains Megestrol acetate, a synthetic progestational agent primarily used in the treatment of certain cancers and as an appetite stimulant. It plays a significant role in managing weight loss and cachexia in patients with AIDS or cancer.

Uses

  • Treatment of advanced breast cancer

  • Treatment of advanced endometrial cancer

  • Management of anorexiacachexia, or significant weight loss in patients with AIDS or cancer

Mechanism of Action

Megestrol acetate works by inhibiting the release of gonadotropins from the pituitary gland, resulting in decreased estrogen production, which is beneficial in hormone-sensitive cancers. Additionally, it has appetite-stimulating properties.

Dosage and Administration

Breast Cancer and Endometrial Cancer:

  • Recommended dose: 40 to 320 mg/day orally, divided into several doses.

Anorexia, Cachexia, or Weight Loss:

  • Recommended dose: 400 to 800 mg/day orally.

  • Administration: Take Benzace with or without food as directed by a healthcare provider.

Missed Dose: Take the missed dose as soon as you remember unless it is close to the next scheduled dose.

Overdose: In case of overdose, seek immediate medical attention.

Side Effects

Common side effects:

  • Weight gain

  • Increased appetite

  • Nausea

  • Weakness

  • Hypertension

  • Mood changes

Serious side effects:

  • Thrombophlebitis

  • Pulmonary embolism

  • Adrenal insufficiency

Precautions

  • Monitor for signs of thromboembolic disorders.

  • Regularly check blood sugar levels in diabetic patients.

  • Use cautiously in patients with a history of deep vein thrombosis or pulmonary embolism.

Contraindications

  • Pregnancy: Benzace is contraindicated in pregnancy due to potential harm to the fetus.

  • Known hypersensitivity to megestrol acetate or any of its components.

Drug Interactions

  • Rifampin and other enzyme inducers may reduce the effectiveness of Benzace.

  • Insulin or oral hypoglycemic agents may require dosage adjustments.

Storage

  • Store at room temperature between 15°C to 30°C.

  • Keep out of reach of children.


Benzace 40mg Tablet Benefits & Uses

Benzace 40mg Tablet is used to treat the following -

Main Benefits

Other Benefits

Benzace 40mg Tablet Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult(Female)
  • Disease: Breast Cancer
  • Before or After Meal: Either
  • Single Maximum Dose: 160 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 1 daily
  • Course Duration: As directed by the doctor
  • Special Instructions: As prescribed by the doctor
Adult
  • Disease: Anorexia Nervosa
  • Before or After Meal: Either
  • Single Maximum Dose: 800 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 1 daily
  • Course Duration: As directed by the doctor
  • Special Instructions: As prescribed by the doctor
Geriatric
  • Disease: Breast Cancer
  • Before or After Meal: Either
  • Single Maximum Dose: 160 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 1 daily
  • Course Duration: As directed by the doctor
  • Special Instructions: As prescribed by the doctor

Benzace 40mg Tablet Side Effects

Based on research, the following side effects have been observed when Benzace 40mg Tablet is used -

Moderate

Mild

Benzace 40mg Tablet Related Warnings

  • Is the use of Benzace 40mg Tablet safe for pregnant women?


    Benzace has many dangerous side effects in pregnant women. If you are pregnant, do not consume Benzace without medical advice.

    Severe
  • Is the use of Benzace 40mg Tablet safe during breastfeeding?


    Women who are breastfeeding may experience severe harmful effects after taking Benzace. It should only be taken after medical advice.

    Severe
  • What is the effect of Benzace 40mg Tablet on the Kidneys?


    Benzace has very mild side effects on the kidneys.

    Mild
  • What is the effect of Benzace 40mg Tablet on the Liver?


    Side effects of Benzace rarely affect the liver.

    Mild
  • What is the effect of Benzace 40mg Tablet on the Heart?


    Very few cases of side effects of Benzace on the heart have been reported.

    Mild

Severe Interaction of Benzace 40mg Tablet with Other Drugs

Benzace 40mg Tablet should not be taken with following medicines due to severe side effects it may cause to patients -

Severe

Moderate


Benzace 40mg Tablet Contraindications

If you are suffering from any of the following diseases, you should not take Benzace 40mg Tablet unless your doctor advises you to do so -


Frequently asked Questions about Benzace 40mg Tablet

  • Is this Benzace 40mg Tablet habit forming or addictive?


    No, there is no any evidence that Benzace 40mg Tablet is addictive.

    No
  • Is it safe to drive or operate heavy machinery when consuming?


    After taking Benzace 40mg Tablet you may feel sleepy. So it is not advised to perform these activities.

    Dangerous
  • Is it safe?


    Yes, but consume Benzace 40mg Tablet only on doctor's advice.

    Safe, but take only on Doctor's advise
  • Is it able to treat mental disorders?


    There is no benefit of taking Benzace 40mg Tablet for mental disorders.

    No

Benzace 40mg Tablet Interactions with Food and Alcohol

  • Interaction between Food and Benzace 40mg Tablet


    Taking Benzace 40mg Tablet with food does not harm your health.

    Safe
  • Interaction between Alcohol and Benzace 40mg Tablet


    It is difficult to say anything about the effect of Benzace 40mg Tablet and alcohol. No research has been done on this yet.

    Unknown

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This medicine data has been created by -

Vikas Chauhan

B.Pharma, Pharmacy
5 Years of Experience


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